Central precocious puberty in girls aged 6 to 8 years and magnetic resonance imaging of the pituitary: 11-year experience in a single centre

Results One hundred and eighty-eight girls had central precocious puberty in the study period and 157 of them (83.5%) had MRI of the pituitary done as part of the workup. The prevalence of intracranial pathology among girls with CPP aged 6 to 8 years was 20.0% while among all girls with CPP aged less than 8 years, 34 girls (21.7%) were found to have intracranial pathology. These pathologies included: pituitary adenoma (n = 16), pineal cyst (n = 8), Rathke’s cleft cysts (n = 4), arachnoid cyst (n = 1), intra-ventricular cyst (n = 1), venous angioma over the left frontal lobe (n = 1), hydrocephalus (n = 2) and an old infarct over the frontal lobe (n = 1). The two cases of hydrocephalus and the case with an old infarct were known before the onset of CPP. None of the lesions detected required further interventions with surgical removal, chemotherapy or radiotherapy within the follow-up period of 7.2 ± 3.0 years.